Clofibrate and fat embolism.

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Injury, serum lipids, fat embolism, and clofibrate.

The mechanism of fat embolism following injury has excited much controversy since it was first described by Zenker in 1862. Two theories seek to explain it-the classical mechanical theory, which is supported by Sevitt (1962), and the metabolic theory, which is supported by Evarts (1965). The mechanical theory suggests that following trauma fat is liberated from the marrow cavity into the venous...

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Clofibrate and fat embolism: a double-blind trial of the effects of clofibrate on sequelae to injury.

In a double-blind prospective trial clofibrate was found not to influence significantly the clinical and laboratory indices thought to reflect the state of fat embolism in patients with fractures.

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Fat embolism.

The importance of fat embolism as a complication of bony trauma has been recognized for over 100 years. During this time there have been short bursts of rapid progress in knowledge and understanding of the problem separated by periods of confusion and misunderstandings. Presently, as a result of improvements in technology, new information has been derived to reduce significantly the morbidity a...

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[Fat embolism].

Fat embolism syndrome is a collection of respiratory, haematological, neurological and cutaneous symptoms and signs associated with trauma and other disparate surgical and medical conditions. The incidence of the clinical syndrome is low (< 1% in retrospective reviews) whilst the embolisation of marrow fat appears to be an almost inevitable consequence of long bone fractures. There is debate ov...

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Fat Embolism *

As one might suppose, the patho-physiological aspects of this question are quite diversified and complex. Hoffheinz's approach to this phase of the subject has done much to integrate the symptomcomplex of fat embolism. One might well turn to physico-dynamics in an endeavor to explain the cause of impaction of fat particles. In his monograph Beneke states that the cohesive force of fat particles...

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ژورنال

عنوان ژورنال: BMJ

سال: 1972

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.3.5824.473